Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells

A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin...

Descripción completa

Detalles Bibliográficos
Autores principales: Chang, Sheng, Yin, Shi-Liang, Wang, Jian, Jing, Yong-Kui, Dong, Jin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254841/
https://www.ncbi.nlm.nih.gov/pubmed/19924055
http://dx.doi.org/10.3390/molecules14104166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254841/
https://www.ncbi.nlm.nih.gov/pubmed/19924055
http://dx.doi.org/10.3390/molecules14104166

Ejemplares similares