Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells

A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin...

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Autores principales: Chang, Sheng, Yin, Shi-Liang, Wang, Jian, Jing, Yong-Kui, Dong, Jin-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254841/
https://www.ncbi.nlm.nih.gov/pubmed/19924055
http://dx.doi.org/10.3390/molecules14104166
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author Chang, Sheng
Yin, Shi-Liang
Wang, Jian
Jing, Yong-Kui
Dong, Jin-Hua
author_facet Chang, Sheng
Yin, Shi-Liang
Wang, Jian
Jing, Yong-Kui
Dong, Jin-Hua
author_sort Chang, Sheng
collection PubMed
description A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]acryla- mide(12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571.
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spelling pubmed-62548412018-11-30 Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells Chang, Sheng Yin, Shi-Liang Wang, Jian Jing, Yong-Kui Dong, Jin-Hua Molecules Article A series of novel 2-phenylaminopyrimidine (PAP) derivatives structurally related to STI-571 were designed and synthesized. The abilities of these compounds to inhibit proliferation were tested in human chronic myeloid leukemia K562 cells. (E)-3-(2-bromophenyl)-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)phenyl]acryla- mide(12d) was the most effective cell growth inhibitor and was 3-fold more potent than STI-571. Molecular Diversity Preservation International 2009-10-19 /pmc/articles/PMC6254841/ /pubmed/19924055 http://dx.doi.org/10.3390/molecules14104166 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chang, Sheng
Yin, Shi-Liang
Wang, Jian
Jing, Yong-Kui
Dong, Jin-Hua
Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells
title Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells
title_full Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells
title_fullStr Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells
title_full_unstemmed Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells
title_short Design and Synthesis of Novel 2-Phenylaminopyrimidine (PAP) Derivatives and Their Antiproliferative Effects in Human Chronic Myeloid Leukemia Cells
title_sort design and synthesis of novel 2-phenylaminopyrimidine (pap) derivatives and their antiproliferative effects in human chronic myeloid leukemia cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254841/
https://www.ncbi.nlm.nih.gov/pubmed/19924055
http://dx.doi.org/10.3390/molecules14104166
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