Synthesis of Lipoamino Acids and Their Activity against Cerebral Ischemic Injury

A series of lipoamino acids were synthesized and their neuroprotective effect against brain ischemia induced by oxygen-glucose deprivation (OGD) on rat cerebral slices was evaluated. Among these compounds, N-stearoyl-l-tyrosine (4), N-stearoyl-l-serine (5) and N-stearoyl-L-threonine (6) exhibited go...

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Detalles Bibliográficos
Autores principales: Yao, Li-Yun, Lin, Qi, Niu, Yin-Yao, Deng, Ke-Min, Zhang, Jian-Hua, Lu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255101/
https://www.ncbi.nlm.nih.gov/pubmed/19924046
http://dx.doi.org/10.3390/molecules14104051
Descripción
Sumario:A series of lipoamino acids were synthesized and their neuroprotective effect against brain ischemia induced by oxygen-glucose deprivation (OGD) on rat cerebral slices was evaluated. Among these compounds, N-stearoyl-l-tyrosine (4), N-stearoyl-l-serine (5) and N-stearoyl-L-threonine (6) exhibited good neuroprotective activity. We found that the neuroprotective activity of lipoamino acids depended on the acyl group, the presence of a free carboxylic function and a free hydroxyl group at the branched chain of the amino acids. The results also showed that 5 was the most active compound, protecting rat brain slices against OGD as well as hydrogen peroxide (H(2)O(2)) insult at the range of 1–10 M.

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