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A General Synthesis of C8-Arylpurine Phosphoramidites

A general scheme for the synthesis of C8-arylpurine phosphoramidites has been developed. C8-Arylation of C8-bromo-2′-deoxyguanosine is the key step and has been achieved through the use of a Suzuki coupling. Since the coupling reaction is conducted under aqueous conditions, it is unnecessary to prot...

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Detalles Bibliográficos
Autores principales: Vongsutilers, Vorasit, Daft, Jonathan R., Shaughnessy, Kevin H., Gannett, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255102/
https://www.ncbi.nlm.nih.gov/pubmed/19783928
http://dx.doi.org/10.3390/molecules14093339