Bystander or No Bystander for Gene Directed Enzyme Prodrug Therapy

Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of chemotherapy by gene transfer, thus enabling target cells to convert non-toxic prodrugs to cytotoxic drugs. A zone of cell kill around gene-modified cells due to transfer of toxic metabolites, known as the byst...

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Detalles Bibliográficos
Autores principales: Dachs, Gabi U., Hunt, Michelle A., Syddall, Sophie, Singleton, Dean C., Patterson, Adam V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255103/
https://www.ncbi.nlm.nih.gov/pubmed/19924084
http://dx.doi.org/10.3390/molecules14114517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255103/
https://www.ncbi.nlm.nih.gov/pubmed/19924084
http://dx.doi.org/10.3390/molecules14114517

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