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Evolution of weak cooperative interactions for biological specificity

A hallmark of biological systems is that particular functions and outcomes are realized in specific contexts, such as when particular signals are received. One mechanism for mediating specificity is described by Fisher’s “lock and key” metaphor, exemplified by enzymes that bind selectively to a part...

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Detalles Bibliográficos
Autores principales: Gao, Ang, Shrinivas, Krishna, Lepeudry, Paul, Suzuki, Hiroshi I., Sharp, Phillip A., Chakraborty, Arup K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255166/
https://www.ncbi.nlm.nih.gov/pubmed/30404915
http://dx.doi.org/10.1073/pnas.1815912115