Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

Recessive Stargardt disease (STGD1) is an inherited blinding disorder caused by mutations in the Abca4 gene. ABCA4 is a flippase in photoreceptor outer segments (OS) that translocates retinaldehyde conjugated to phosphatidylethanolamine across OS disc membranes. Loss of ABCA4 in Abca4(−/−) mice and...

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Detalles Bibliográficos
Autores principales: Lenis, Tamara L., Hu, Jane, Ng, Sze Yin, Jiang, Zhichun, Sarfare, Shanta, Lloyd, Marcia B., Esposito, Nicholas J., Samuel, William, Jaworski, Cynthia, Bok, Dean, Finnemann, Silvia C., Radeke, Monte J., Redmond, T. Michael, Travis, Gabriel H., Radu, Roxana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255167/
https://www.ncbi.nlm.nih.gov/pubmed/30397118
http://dx.doi.org/10.1073/pnas.1802519115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255167/
https://www.ncbi.nlm.nih.gov/pubmed/30397118
http://dx.doi.org/10.1073/pnas.1802519115

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