Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model

Alzheimer’s disease (AD) is the leading cause of age-related dementia. Neuropathological hallmarks of AD include brain deposition of β-amyloid (Aβ) plaques and accumulation of both hyperphosphorylated and acetylated tau. RGFP-966, a brain-penetrant and selective HDAC3 inhibitor, or HDAC3 silencing,...

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Detalles Bibliográficos
Autores principales: Janczura, Karolina J., Volmar, Claude-Henry, Sartor, Gregory C., Rao, Sunil J., Ricciardi, Natalie R., Lambert, Guerline, Brothers, Shaun P., Wahlestedt, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255210/
https://www.ncbi.nlm.nih.gov/pubmed/30397132
http://dx.doi.org/10.1073/pnas.1805436115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255210/
https://www.ncbi.nlm.nih.gov/pubmed/30397132
http://dx.doi.org/10.1073/pnas.1805436115

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