Cargando…
Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics
Multiple mutations are typically required to significantly improve protein stability or aggregation kinetics. However, when several substitutions are made in a single protein, the mutations can potentially interact in a nonadditive manner, resulting in epistatic effects, which can hamper protein-eng...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255212/ https://www.ncbi.nlm.nih.gov/pubmed/30404916 http://dx.doi.org/10.1073/pnas.1810324115 |