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Coupled molecular dynamics mediate long- and short-range epistasis between mutations that affect stability and aggregation kinetics

Multiple mutations are typically required to significantly improve protein stability or aggregation kinetics. However, when several substitutions are made in a single protein, the mutations can potentially interact in a nonadditive manner, resulting in epistatic effects, which can hamper protein-eng...

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Detalles Bibliográficos
Autores principales: Yu, Haoran, Dalby, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255212/
https://www.ncbi.nlm.nih.gov/pubmed/30404916
http://dx.doi.org/10.1073/pnas.1810324115

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