Synthesis, Structural Studies and Antitumoral Evaluation of C-6 Alkyl and Alkenyl Side Chain Pyrimidine Derivatives

The synthetic route for introduction of fluorophenylalkyl (compounds 5, 7, 14 and 15) and fluorophenylalkenyl (compounds 4E and 13) side chains at C-6 of the pyrimidine nucleus involved the lithiation of the pyrimidine derivatives 1, 2 and 11 and subsequent nucleophilic addition or substitution reac...

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Detalles Bibliográficos
Autores principales: Krištafor, Svjetlana, Gazivoda Kraljević, Tatjana, Makuc, Damjan, Plavec, Janez, Šuman, Lidija, Kralj, Marijeta, Raić-Malić, Silvana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255265/
https://www.ncbi.nlm.nih.gov/pubmed/20032865
http://dx.doi.org/10.3390/molecules14124866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255265/
https://www.ncbi.nlm.nih.gov/pubmed/20032865
http://dx.doi.org/10.3390/molecules14124866

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