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Carnitine Conjugate of Nipecotic Acid: A New Example of Dual Prodrug

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

Detalles Bibliográficos
Autores principales: Napolitano, Carmela, Scaglianti, Martina, Scalambra, Emanuela, Manfredini, Stefano, Ferraro, Luca, Beggiato, Sarah, Vertuani, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255320/
https://www.ncbi.nlm.nih.gov/pubmed/19783924
http://dx.doi.org/10.3390/molecules14093268