540. Investigating the Mechanism of a Unique Human Immunodeficiency Virus-1 (HIV-1) Entry Inhibitor, MF275

BACKGROUND: HIV-1 entry into cells is mediated by sequential binding of target cell CD4 and CCR5 or CXCR4 to the metastable envelope (Env) trimer of gp120-gp41 heterodimers (Figure 1). We determined that MF275, a single diastereomer of the small molecule entry inhibitor PF-68742, is necessary and su...

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Detalles Bibliográficos
Autores principales: Zhao, Connie, Princiotto, Amy, Farrell, Mark, Smith III, Amos B, Madani, Navid, Sodroski, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Abstracts
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255539/
http://dx.doi.org/10.1093/ofid/ofy210.549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255539/
http://dx.doi.org/10.1093/ofid/ofy210.549

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