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IKKβ activates p53 to promote cancer cell adaptation to glutamine deprivation

One of the hallmarks of cancer is the ability to reprogram cellular metabolism to increase the uptake of necessary nutrients such as glucose and glutamine. Driven by oncogenes, cancer cells have increased glutamine uptake to support their highly proliferative nature. However, as cancer cells continu...

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Detalles Bibliográficos
Autores principales: Ishak Gabra, Mari B., Yang, Ying, Lowman, Xazmin H., Reid, Michael A., Tran, Thai Q., Kong, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255781/
https://www.ncbi.nlm.nih.gov/pubmed/30478303
http://dx.doi.org/10.1038/s41389-018-0104-0