Ternary crystal structure of human RORγ ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction

Retinoic acid-related orphan receptor gamma (RORγ) plays pivotal roles in autoimmune diseases by controlling the lineage of interleukin 17 (IL-17)-producing CD4(+) T cells (Th17 cells). Structure-based drug design has proven fruitful in the development of inhibitors targeting the ligand binding doma...

Descripción completa

Detalles Bibliográficos
Autores principales: Noguchi, Masato, Nomura, Akihiro, Doi, Satoki, Yamaguchi, Keishi, Hirata, Kazuyuki, Shiozaki, Makoto, Maeda, Katsuya, Hirashima, Shintaro, Kotoku, Masayuki, Yamaguchi, Takayuki, Katsuda, Yoshiaki, Crowe, Paul, Tao, Haiyan, Thacher, Scott, Adachi, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255837/
https://www.ncbi.nlm.nih.gov/pubmed/30478402
http://dx.doi.org/10.1038/s41598-018-35783-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255837/
https://www.ncbi.nlm.nih.gov/pubmed/30478402
http://dx.doi.org/10.1038/s41598-018-35783-9

Ejemplares similares