HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts

Placental hypoxia and elevated levels of circulating soluble Fms-like tyrosine kinase-1 (sFlt-1), an anti-angiogenic factor, are closely related to the pathogenesis of preeclampsia. Although sFlt-1 secretion from the placental trophoblasts is increased under hypoxic conditions, the underlying molecu...

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Detalles Bibliográficos
Autores principales: Sasagawa, Tadashi, Nagamatsu, Takeshi, Morita, Kazuki, Mimura, Nobuko, Iriyama, Takayuki, Fujii, Tomoyuki, Shibuya, Masabumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255857/
https://www.ncbi.nlm.nih.gov/pubmed/30478339
http://dx.doi.org/10.1038/s41598-018-35745-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255857/
https://www.ncbi.nlm.nih.gov/pubmed/30478339
http://dx.doi.org/10.1038/s41598-018-35745-1

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