High glycolytic activity of tumor cells leads to underestimation of electron transport system capacity when mitochondrial ATP synthase is inhibited

This study sought to elucidate how oligomycin, an ATP synthase blocker, leads to underestimation of maximal oxygen consumption rate ((max)OCR) and spare respiratory capacity (SRC) in tumor cells. T98G and U-87MG glioma cells were titrated with the protonophore CCCP to induce (max)OCR. The presence o...

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Detalles Bibliográficos
Autores principales: Ruas, Juliana S., Siqueira-Santos, Edilene S., Rodrigues-Silva, Erika, Castilho, Roger F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255871/
https://www.ncbi.nlm.nih.gov/pubmed/30478338
http://dx.doi.org/10.1038/s41598-018-35679-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255871/
https://www.ncbi.nlm.nih.gov/pubmed/30478338
http://dx.doi.org/10.1038/s41598-018-35679-8

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