BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation

Assembly of the CARD11/CARMA1-BCL10-MALT1 (CBM) signaling complex upon T or B cell antigen receptor (TCR or BCR) engagement drives lymphocyte activation. Recruitment of pre-assembled BCL10-MALT1 complexes to CARD11 fosters activation of the MALT1 protease and canonical NF-κB signaling. Structural da...

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Detalles Bibliográficos
Autores principales: Seeholzer, Thomas, Kurz, Susanne, Schlauderer, Florian, Woods, Simone, Gehring, Torben, Widmann, Simon, Lammens, Katja, Krappmann, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255920/
https://www.ncbi.nlm.nih.gov/pubmed/30515170
http://dx.doi.org/10.3389/fimmu.2018.02695

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255920/
https://www.ncbi.nlm.nih.gov/pubmed/30515170
http://dx.doi.org/10.3389/fimmu.2018.02695

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