New Approaches to Tay-Sachs Disease Therapy

Tay-Sachs disease belongs to the group of autosomal-recessive lysosomal storage metabolic disorders. This disease is caused by β-hexosaminidase A (HexA) enzyme deficiency due to various mutations in α-subunit gene of this enzyme, resulting in GM2 ganglioside accumulation predominantly in lysosomes o...

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Detalles Bibliográficos
Autores principales: Solovyeva, Valeriya V., Shaimardanova, Alisa A., Chulpanova, Daria S., Kitaeva, Kristina V., Chakrabarti, Lisa, Rizvanov, Albert A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256099/
https://www.ncbi.nlm.nih.gov/pubmed/30524313
http://dx.doi.org/10.3389/fphys.2018.01663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256099/
https://www.ncbi.nlm.nih.gov/pubmed/30524313
http://dx.doi.org/10.3389/fphys.2018.01663

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