Amixicile Reduces Severity of Cryptosporidiosis but Does Not Have In Vitro Activity against Cryptosporidium

Cryptosporidium species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of NTZ diminishes...

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Detalles Bibliográficos
Autores principales: Bartelt, Luther A., Bolick, David T., Kolling, Glynis L., Stebbins, Erin, Huston, Christopher D., Guerrant, Richard L., Hoffman, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256802/
https://www.ncbi.nlm.nih.gov/pubmed/30297368
http://dx.doi.org/10.1128/AAC.00718-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256802/
https://www.ncbi.nlm.nih.gov/pubmed/30297368
http://dx.doi.org/10.1128/AAC.00718-18

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