Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins †

A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as wel...

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Autores principales: Quezada, Elías, Delogu, Giovanna, Picciau, Carmen, Santana, Lourdes, Podda, Gianni, Borges, Fernanda, García-Morales, Verónica, Viña, Dolores, Orallo, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257048/
https://www.ncbi.nlm.nih.gov/pubmed/20110890
http://dx.doi.org/10.3390/molecules15010270
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author Quezada, Elías
Delogu, Giovanna
Picciau, Carmen
Santana, Lourdes
Podda, Gianni
Borges, Fernanda
García-Morales, Verónica
Viña, Dolores
Orallo, Francisco
author_facet Quezada, Elías
Delogu, Giovanna
Picciau, Carmen
Santana, Lourdes
Podda, Gianni
Borges, Fernanda
García-Morales, Verónica
Viña, Dolores
Orallo, Francisco
author_sort Quezada, Elías
collection PubMed
description A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives.
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spelling pubmed-62570482018-12-03 Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins † Quezada, Elías Delogu, Giovanna Picciau, Carmen Santana, Lourdes Podda, Gianni Borges, Fernanda García-Morales, Verónica Viña, Dolores Orallo, Francisco Molecules Article A series of 6-halo-3-hydroxyphenylcoumarins (resveratrol-coumarins hybrid derivatives) was synthesized in good yields by a Perkin reaction followed by hydrolysis. The new compounds were evaluated for their vasorelaxant activity in intact rat aorta rings pre-contracted with phenylephrine (PE), as well as for their inhibitory effects on platelet aggregation induced by thrombin in washed human platelets. These compounds concentration-dependently relaxed vascular smooth muscle and some of them showed a platelet antiaggregatory activity that was up to thirty times higher than that shown by trans-resveratrol and some other previously synthesized derivatives. Molecular Diversity Preservation International 2010-01-12 /pmc/articles/PMC6257048/ /pubmed/20110890 http://dx.doi.org/10.3390/molecules15010270 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Quezada, Elías
Delogu, Giovanna
Picciau, Carmen
Santana, Lourdes
Podda, Gianni
Borges, Fernanda
García-Morales, Verónica
Viña, Dolores
Orallo, Francisco
Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins †
title Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins †
title_full Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins †
title_fullStr Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins †
title_full_unstemmed Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins †
title_short Synthesis and Vasorelaxant and Platelet Antiaggregatory Activities of a New Series of 6-Halo-3-phenylcoumarins †
title_sort synthesis and vasorelaxant and platelet antiaggregatory activities of a new series of 6-halo-3-phenylcoumarins †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257048/
https://www.ncbi.nlm.nih.gov/pubmed/20110890
http://dx.doi.org/10.3390/molecules15010270
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