An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines

A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl(3). The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, a...

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Autores principales: Begum, Sabira, Zubair, Farhat, Nawazish Ali, Syed, Shaheen Siddiqui, Bina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257112/
https://www.ncbi.nlm.nih.gov/pubmed/20110872
http://dx.doi.org/10.3390/molecules15010068
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author Begum, Sabira
Zubair, Farhat
Nawazish Ali, Syed
Shaheen Siddiqui, Bina
author_facet Begum, Sabira
Zubair, Farhat
Nawazish Ali, Syed
Shaheen Siddiqui, Bina
author_sort Begum, Sabira
collection PubMed
description A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl(3). The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines.
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spelling pubmed-62571122018-12-03 An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines Begum, Sabira Zubair, Farhat Nawazish Ali, Syed Shaheen Siddiqui, Bina Molecules Article A facile synthesis of a series of benzene ring acylated analogues of harmaline has been achieved by Friedel-Crafts acylation under solvent-free conditions at room temperature using acyl halides/acid anhydrides and AlCl(3). The reaction afforded 10- and 12-acyl analogues of harmaline in good yield, along with minor quantities of N-acyl-tryptamines and 8-acyl analogues of N-acyltryptamines. Molecular Diversity Preservation International 2009-12-28 /pmc/articles/PMC6257112/ /pubmed/20110872 http://dx.doi.org/10.3390/molecules15010068 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Begum, Sabira
Zubair, Farhat
Nawazish Ali, Syed
Shaheen Siddiqui, Bina
An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines
title An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines
title_full An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines
title_fullStr An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines
title_full_unstemmed An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines
title_short An Efficient, Mild and Solvent-Free Synthesis of Benzene Ring Acylated Harmalines
title_sort efficient, mild and solvent-free synthesis of benzene ring acylated harmalines
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257112/
https://www.ncbi.nlm.nih.gov/pubmed/20110872
http://dx.doi.org/10.3390/molecules15010068
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