Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles

The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions...

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Autores principales: El-Kashef, Hussein, Farghaly, Abdel-Rahman, Al-Hazmi, Ahmed, Terme, Thierry, Vanelle, Patrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257348/
https://www.ncbi.nlm.nih.gov/pubmed/20428071
http://dx.doi.org/10.3390/molecules15042651
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author El-Kashef, Hussein
Farghaly, Abdel-Rahman
Al-Hazmi, Ahmed
Terme, Thierry
Vanelle, Patrice
author_facet El-Kashef, Hussein
Farghaly, Abdel-Rahman
Al-Hazmi, Ahmed
Terme, Thierry
Vanelle, Patrice
author_sort El-Kashef, Hussein
collection PubMed
description The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4',3':4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.
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spelling pubmed-62573482018-11-30 Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles El-Kashef, Hussein Farghaly, Abdel-Rahman Al-Hazmi, Ahmed Terme, Thierry Vanelle, Patrice Molecules Article The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4',3':4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented. Molecular Diversity Preservation International 2010-04-12 /pmc/articles/PMC6257348/ /pubmed/20428071 http://dx.doi.org/10.3390/molecules15042651 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
El-Kashef, Hussein
Farghaly, Abdel-Rahman
Al-Hazmi, Ahmed
Terme, Thierry
Vanelle, Patrice
Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
title Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
title_full Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
title_fullStr Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
title_full_unstemmed Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
title_short Pyridine-Based Heterocycles. Synthesis of New Pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and Related Heterocycles
title_sort pyridine-based heterocycles. synthesis of new pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and related heterocycles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257348/
https://www.ncbi.nlm.nih.gov/pubmed/20428071
http://dx.doi.org/10.3390/molecules15042651
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