Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and targ...

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Detalles Bibliográficos
Autores principales: Yin, Xiao Jia, Xu, Guan Hong, Sun, Xu, Peng, Yan, Ji, Xing, Jiang, Ke, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257562/
https://www.ncbi.nlm.nih.gov/pubmed/20657439
http://dx.doi.org/10.3390/molecules15064261

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257562/
https://www.ncbi.nlm.nih.gov/pubmed/20657439
http://dx.doi.org/10.3390/molecules15064261

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