Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and targ...

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Detalles Bibliográficos
Autores principales: Yin, Xiao Jia, Xu, Guan Hong, Sun, Xu, Peng, Yan, Ji, Xing, Jiang, Ke, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257562/
https://www.ncbi.nlm.nih.gov/pubmed/20657439
http://dx.doi.org/10.3390/molecules15064261
Descripción
Sumario:This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC.

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