Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and targ...

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Detalles Bibliográficos
Autores principales: Yin, Xiao Jia, Xu, Guan Hong, Sun, Xu, Peng, Yan, Ji, Xing, Jiang, Ke, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257562/
https://www.ncbi.nlm.nih.gov/pubmed/20657439
http://dx.doi.org/10.3390/molecules15064261
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author Yin, Xiao Jia
Xu, Guan Hong
Sun, Xu
Peng, Yan
Ji, Xing
Jiang, Ke
Li, Fei
author_facet Yin, Xiao Jia
Xu, Guan Hong
Sun, Xu
Peng, Yan
Ji, Xing
Jiang, Ke
Li, Fei
author_sort Yin, Xiao Jia
collection PubMed
description This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC.
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spelling pubmed-62575622018-12-04 Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid Yin, Xiao Jia Xu, Guan Hong Sun, Xu Peng, Yan Ji, Xing Jiang, Ke Li, Fei Molecules Article This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by (1)H-NMR, (13)C-NMR, MS and the purities of all the compounds were determined by HPLC. MDPI 2010-06-11 /pmc/articles/PMC6257562/ /pubmed/20657439 http://dx.doi.org/10.3390/molecules15064261 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yin, Xiao Jia
Xu, Guan Hong
Sun, Xu
Peng, Yan
Ji, Xing
Jiang, Ke
Li, Fei
Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
title Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
title_full Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
title_fullStr Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
title_full_unstemmed Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
title_short Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid
title_sort synthesis of bosutinib from 3-methoxy-4-hydroxybenzoic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257562/
https://www.ncbi.nlm.nih.gov/pubmed/20657439
http://dx.doi.org/10.3390/molecules15064261
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