Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers

Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.

Detalles Bibliográficos
Autores principales: de Vega, Mª Jesús Pérez, García-López, Mª Teresa, Zaccaro, Laura, Royo, Miriam, Albericio, Fernando, Fernández-Carvajal, Asia, Ferrer-Montiel, Antonio, González-Muñiz, Rosario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257583/
https://www.ncbi.nlm.nih.gov/pubmed/20657400
http://dx.doi.org/10.3390/molecules15074924
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author de Vega, Mª Jesús Pérez
García-López, Mª Teresa
Zaccaro, Laura
Royo, Miriam
Albericio, Fernando
Fernández-Carvajal, Asia
Ferrer-Montiel, Antonio
González-Muñiz, Rosario
author_facet de Vega, Mª Jesús Pérez
García-López, Mª Teresa
Zaccaro, Laura
Royo, Miriam
Albericio, Fernando
Fernández-Carvajal, Asia
Ferrer-Montiel, Antonio
González-Muñiz, Rosario
author_sort de Vega, Mª Jesús Pérez
collection PubMed
description Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists.
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spelling pubmed-62575832018-12-06 Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers de Vega, Mª Jesús Pérez García-López, Mª Teresa Zaccaro, Laura Royo, Miriam Albericio, Fernando Fernández-Carvajal, Asia Ferrer-Montiel, Antonio González-Muñiz, Rosario Molecules Article Trp(Nps)-Lys-NH(2) derivatives, bearing alkyl or guanidine groups either at the N–terminus or on the Lys side-chain or at both positions were conveniently prepared on solid-phase and evaluated as TRPV1 channel antagonists. MDPI 2010-07-15 /pmc/articles/PMC6257583/ /pubmed/20657400 http://dx.doi.org/10.3390/molecules15074924 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
de Vega, Mª Jesús Pérez
García-López, Mª Teresa
Zaccaro, Laura
Royo, Miriam
Albericio, Fernando
Fernández-Carvajal, Asia
Ferrer-Montiel, Antonio
González-Muñiz, Rosario
Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers
title Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers
title_full Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers
title_fullStr Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers
title_full_unstemmed Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers
title_short Solid-Phase Synthesis of New Trp(Nps)-Containing Dipeptide Derivatives as TRPV1 Channel Blockers
title_sort solid-phase synthesis of new trp(nps)-containing dipeptide derivatives as trpv1 channel blockers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257583/
https://www.ncbi.nlm.nih.gov/pubmed/20657400
http://dx.doi.org/10.3390/molecules15074924
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