Bisbenzamidines as Antifungal Agents. Are Both Amidine Functions Required to Observe an Anti-Pneumocystis carinii Activity?

A library of 19 novel 4-(4-phenylpiperazine-1-yl)benzamidines has been synthesized and evaluated in vitro against Pneumocystis carinii. Among these compounds, N-ethyl- and N-hexyl-4-(4-phenylpiperazine-1-yl)benzamidines emerged as the most promising compounds, with inhibition percentages at 10.0 µg/...

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Detalles Bibliográficos
Autores principales: Laurent, Julien, Stanicki, Dimitri, Huang, Tien L., Dei-Cas, Eduardo, Pottier, Muriel, Aliouat, El Mouktar, Vanden Eynde, Jean Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257595/
https://www.ncbi.nlm.nih.gov/pubmed/20657441
http://dx.doi.org/10.3390/molecules15064283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257595/
https://www.ncbi.nlm.nih.gov/pubmed/20657441
http://dx.doi.org/10.3390/molecules15064283

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