Synthesis of Chiral Macrocyclic or Linear Pyridine Carboxamides from Pyridine-2,6-dicarbonyl Dichloride as Antimicrobial Agents

A series of chiral linear and macrocyclic bridged pyridines has been prepared starting from pyridine-2,6-dicarbonyl dichloride (2). The coupling of 1 with D-alanyl methyl ester gave 2,6-bis-D-alanyl pyridine methyl ester (3). Hydrazinolysis of 3 with hydrazine hydrate afforded bis-hydrazide 4. The l...

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Detalles Bibliográficos
Autores principales: Al-Salahi, Rashad A., Al-Omar, Mohamed A., Amr, Abd El-Galil E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257722/
https://www.ncbi.nlm.nih.gov/pubmed/20877246
http://dx.doi.org/10.3390/molecules15096588

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257722/
https://www.ncbi.nlm.nih.gov/pubmed/20877246
http://dx.doi.org/10.3390/molecules15096588

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