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Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on th...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257754/ https://www.ncbi.nlm.nih.gov/pubmed/20877216 http://dx.doi.org/10.3390/molecules15096193 |
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author | Kolarovic, Jovanka Popovic, Mira Zlinská, Janka Trivic, Svetlana Vojnovic, Matilda |
author_facet | Kolarovic, Jovanka Popovic, Mira Zlinská, Janka Trivic, Svetlana Vojnovic, Matilda |
author_sort | Kolarovic, Jovanka |
collection | PubMed |
description | We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450. |
format | Online Article Text |
id | pubmed-6257754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62577542018-12-06 Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin Kolarovic, Jovanka Popovic, Mira Zlinská, Janka Trivic, Svetlana Vojnovic, Matilda Molecules Article We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450. MDPI 2010-09-03 /pmc/articles/PMC6257754/ /pubmed/20877216 http://dx.doi.org/10.3390/molecules15096193 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Kolarovic, Jovanka Popovic, Mira Zlinská, Janka Trivic, Svetlana Vojnovic, Matilda Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin |
title | Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin |
title_full | Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin |
title_fullStr | Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin |
title_full_unstemmed | Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin |
title_short | Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin |
title_sort | antioxidant activities of celery and parsley juices in rats treated with doxorubicin |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257754/ https://www.ncbi.nlm.nih.gov/pubmed/20877216 http://dx.doi.org/10.3390/molecules15096193 |
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