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Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin

We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on th...

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Autores principales: Kolarovic, Jovanka, Popovic, Mira, Zlinská, Janka, Trivic, Svetlana, Vojnovic, Matilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257754/
https://www.ncbi.nlm.nih.gov/pubmed/20877216
http://dx.doi.org/10.3390/molecules15096193
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author Kolarovic, Jovanka
Popovic, Mira
Zlinská, Janka
Trivic, Svetlana
Vojnovic, Matilda
author_facet Kolarovic, Jovanka
Popovic, Mira
Zlinská, Janka
Trivic, Svetlana
Vojnovic, Matilda
author_sort Kolarovic, Jovanka
collection PubMed
description We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450.
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spelling pubmed-62577542018-12-06 Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin Kolarovic, Jovanka Popovic, Mira Zlinská, Janka Trivic, Svetlana Vojnovic, Matilda Molecules Article We have examined the influence of diluted pure celery and parsley leaf and root juices and their combinations with doxorubicin on the antioxidant status [as measured by the content of reduced glutathione (GSH) and ferric reducing antioxidant power (FRAP)] in liver homogenate and hemolysate and on the contents of cytochrome P450 in liver homogenate. It was found that doxorubicin significantly decreased the content of reduced glutathione and the total antioxidative status (FRAP) in liver homogenate and hemolysate, while celery and parsley juices alone and in combination with doxorubicin had different actions. Doxorubicin and celery juice had no effect on content of cytochrome P450. However, in combination with doxorubicin, parsley root juice significant increased, and parsley leaves juice decreased the cytochrome P450 content (compared to doxorubicin treated animals). Only parsley root juice significantly increased the content of cytochrome P450. MDPI 2010-09-03 /pmc/articles/PMC6257754/ /pubmed/20877216 http://dx.doi.org/10.3390/molecules15096193 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Kolarovic, Jovanka
Popovic, Mira
Zlinská, Janka
Trivic, Svetlana
Vojnovic, Matilda
Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
title Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
title_full Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
title_fullStr Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
title_full_unstemmed Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
title_short Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin
title_sort antioxidant activities of celery and parsley juices in rats treated with doxorubicin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257754/
https://www.ncbi.nlm.nih.gov/pubmed/20877216
http://dx.doi.org/10.3390/molecules15096193
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