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Comment on ‘Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol’

The plasma membrane in mammalian cells is rich in cholesterol, but how the cholesterol is partitioned between the two leaflets of the plasma membrane remains a matter of debate. Recently, Liu et al. used domain 4 (D4) of perfringolysin O as a cholesterol sensor to argue that cholesterol is mostly in...

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Detalles Bibliográficos
Autores principales: Courtney, Kevin C, Fung, Karen YY, Maxfield, Frederick R, Fairn, Gregory D, Zha, Xiaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257810/
https://www.ncbi.nlm.nih.gov/pubmed/30422112
http://dx.doi.org/10.7554/eLife.38493