Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms

Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficient Caenorhabditis elegans by targeting cytoplasmic...

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Detalles Bibliográficos
Autores principales: Solis, Gregory M, Kardakaris, Rozina, Valentine, Elizabeth R, Bar-Peled, Liron, Chen, Alice L, Blewett, Megan M, McCormick, Mark A, Williamson, James R, Kennedy, Brian, Cravatt, Benjamin F, Petrascheck, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257811/
https://www.ncbi.nlm.nih.gov/pubmed/30479271
http://dx.doi.org/10.7554/eLife.40314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257811/
https://www.ncbi.nlm.nih.gov/pubmed/30479271
http://dx.doi.org/10.7554/eLife.40314

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