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Chiral Syn-1,3-diol Derivatives via a One-Pot Diastereoselective Carboxylation/ Bromocyclization of Homoallylic Alcohols

Chiral syn-1,3-diols are fundamental structural motifs in many natural products and drugs. The traditional Narasaka-Prasad diastereoselective reduction from chiral β-hydroxyketones is an important process for the synthesis of these functionalized syn-1,3-diols, but it is of limited applicability for...

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Detalles Bibliográficos
Autores principales: Huang, Guanxin, Liu, Minjie, Xiong, Fangjun, Meng, Ge, Tao, Yuan, Wu, Yan, Peng, Haihui, Chen, Fener
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257933/
https://www.ncbi.nlm.nih.gov/pubmed/30476789
http://dx.doi.org/10.1016/j.isci.2018.11.010