Cargando…

Transcriptome analysis of Shank3-overexpressing mice reveals unique molecular changes in the hypothalamus

Various mutations in the SH3 and multiple ankyrin repeat domains 3 (SHANK3) gene are associated with neurodevelopmental and neuropsychiatric disorders. Thus far, synaptic abnormalities in multiple brain regions, including the hippocampus, prefrontal cortex, striatum, and ventral tegmental area, have...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jin, Chunmei, Kang, Hyojin, Kim, Shinhyun, Zhang, Yinhua, Lee, Yeunkum, Kim, Yoonhee, Han, Kihoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Micro Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257967/ https://www.ncbi.nlm.nih.gov/pubmed/30482234 http://dx.doi.org/10.1186/s13041-018-0413-4

Ejemplares similares

Spontaneous seizure and partial lethality of juvenile Shank3-overexpressing mice in C57BL/6 J background
por: Jin, Chunmei, et al.
Publicado: (2018)

Integrative Brain Transcriptome Analysis Reveals Region-Specific and Broad Molecular Changes in Shank3-Overexpressing Mice
por: Jin, Chunmei, et al.
Publicado: (2018)

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling
por: Lee, Yeunkum, et al.
Publicado: (2017)

Increased ribosomal protein levels and protein synthesis in the striatal synaptosome of Shank3-overexpressing transgenic mice
por: Jin, Chunmei, et al.
Publicado: (2021)

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations
por: Lee, Yeunkum, et al.
Publicado: (2017)

Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons
por: Jin, Chunmei, et al.
Publicado: (2019)

Transcriptome analyses suggest minimal effects of Shank3 dosage on directional gene expression changes in the mouse striatum
por: Lee, Yeunkum, et al.
Publicado: (2019)

Smaller Body Size, Early Postnatal Lethality, and Cortical Extracellular Matrix-Related Gene Expression Changes of Cyfip2-Null Embryonic Mice
por: Zhang, Yinhua, et al.
Publicado: (2019)

Altered presynaptic function and number of mitochondria in the medial prefrontal cortex of adult Cyfip2 heterozygous mice
por: Kim, Gyu Hyun, et al.
Publicado: (2020)

Excitatory and inhibitory synaptic dysfunction in mania: an emerging hypothesis from animal model studies
por: Lee, Yeunkum, et al.
Publicado: (2018)

The emerging roles of Shank3 in cardiac function and dysfunction
por: Kim, Yoonhee, et al.
Publicado: (2023)

The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform
por: Jin, Chunmei, et al.
Publicado: (2021)

Increased social interaction in Shank2-deficient mice following acute social isolation
por: Choi, Ja Eun, et al.
Publicado: (2023)

SHANK3 overexpression causes manic-like behavior with unique pharmacogenetic properties
por: Han, Kihoon, et al.
Publicado: (2013)

Reduced chronic restraint stress in mice overexpressing hyperactive proteasomes in the forebrain
por: Kim, Ji Hyeon, et al.
Publicado: (2020)

In vitro zinc supplementation alters synaptic deficits caused by autism spectrum disorder-associated Shank2 point mutations in hippocampal neurons
por: Vyas, Yukti, et al.
Publicado: (2021)

Bipolar Disorder Associated microRNA, miR-1908-5p, Regulates the Expression of Genes Functioning in Neuronal Glutamatergic Synapses
por: Kim, Yoonhee, et al.
Publicado: (2016)

Brain region and gene dosage-differential transcriptomic changes in Shank2-mutant mice
por: Yoo, Ye-Eun, et al.
Publicado: (2022)

Age, brain region, and gene dosage-differential transcriptomic changes in Shank3-mutant mice
por: Yoo, Taesun, et al.
Publicado: (2022)

Overexpression of activated CaMKII in the CA1 hippocampus impairs context discrimination, but not contextual conditioning
por: Ye, Sanghyun, et al.
Publicado: (2019)

Neuronal function and dysfunction of CYFIP2: from actin dynamics to early infantile epileptic encephalopathy
por: Zhang, Yinhua, et al.
Publicado: (2019)

Gene Dosage- and Age-Dependent Differential Transcriptomic Changes in the Prefrontal Cortex of Shank2-Mutant Mice
por: Lee, Seungjoon, et al.
Publicado: (2021)

Clozapine generates obsessive compulsive disorder-like behavior in mice
por: Kang, Shinwon, et al.
Publicado: (2020)

Autism-like behaviors in male mice with a Pcdh19 deletion
por: Lim, Jisoo, et al.
Publicado: (2019)

Abolished ketamine effects on the spontaneous excitatory postsynaptic current of medial prefrontal cortex neurons in GluN2D knockout mice
por: Han, Dae Hee, et al.
Publicado: (2021)

Modeling PTEN overexpression-induced microcephaly in human brain organoids
por: Dhaliwal, Navroop, et al.
Publicado: (2021)

Early Chronic Memantine Treatment-Induced Transcriptomic Changes in Wild-Type and Shank2-Mutant Mice
por: Yoo, Ye-Eun, et al.
Publicado: (2021)

Identification of stress resilience module by weighted gene co-expression network analysis in Fkbp5-deficient mice
por: Kwon, Joonhong, et al.
Publicado: (2019)

Decreased intrinsic excitability of cerebellar Purkinje cells following optokinetic learning in mice
por: Kim, Yong Gyu, et al.
Publicado: (2020)

A new paradigm of learned cooperation reveals extensive social coordination and specific cortical activation in mice
por: Zhang, Ke-Ming, et al.
Publicado: (2023)

Chronic skin ultraviolet irradiation induces transcriptomic changes associated with microglial dysfunction in the hippocampus
por: Yoon, Kyeong-No, et al.
Publicado: (2022)

Post-transcriptional regulation of SHANK3 expression by microRNAs related to multiple neuropsychiatric disorders
por: Choi, Su-Yeon, et al.
Publicado: (2015)

Transcriptomic profiling of sporadic Alzheimer’s disease patients
por: Caldwell, Andrew B., et al.
Publicado: (2022)

Disruption of the astrocyte–neuron interaction is responsible for the impairments in learning and memory in 5XFAD mice: an Alzheimer’s disease animal model
por: Choi, Moonseok, et al.
Publicado: (2021)

Cell-autonomous reduction of CYFIP2 is insufficient to induce Alzheimer's disease-like pathologies in the hippocampal CA1 pyramidal neurons of aged mice
por: Ma, Ruiying, et al.
Publicado: (2023)

Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish
por: Suzuki, Shiho, et al.
Publicado: (2020)

Enhanced Prefrontal Neuronal Activity and Social Dominance Behavior in Postnatal Forebrain Excitatory Neuron-Specific Cyfip2 Knock-Out Mice
por: Zhang, Yinhua, et al.
Publicado: (2020)

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
por: Wang, Li, et al.
Publicado: (2019)

The acute transcriptome response of the midbrain/diencephalon to injury in the adult mummichog (Fundulus heteroclitus)
por: Bisese, Eleanor C., et al.
Publicado: (2019)

Donepezil ameliorates Aβ pathology but not tau pathology in 5xFAD mice
por: Choi, Hee-Jeong, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3gcjvuqrnrejs166jkuc21g5d1