In vitro and in vivo delivery of a sustained release nanocarrier-based formulation of an MRTF/SRF inhibitor in conjunctival fibrosis

BACKGROUND: Sustained drug delivery is a large unmet clinical need in glaucoma. Here, we incorporated a Myocardin-Related Transcription Factor/Serum Response Factor inhibitor, CCG-222740, into slow release large unilamellar vesicles derived from the liposomes DOTMA (1,2-di-O-octadecenyl-3-trimethyla...

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Detalles Bibliográficos
Autores principales: Tagalakis, Aristides D., Madaan, Shivam, Larsen, Scott D., Neubig, Richard R., Khaw, Peng T., Rodrigues, Ian, Goyal, Saurabh, Lim, Kin Sheng, Yu-Wai-Man, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258153/
https://www.ncbi.nlm.nih.gov/pubmed/30482196
http://dx.doi.org/10.1186/s12951-018-0425-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258153/
https://www.ncbi.nlm.nih.gov/pubmed/30482196
http://dx.doi.org/10.1186/s12951-018-0425-3

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