Primate immunodeficiency virus Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex

Host factors that silence provirus transcription in CD4(+) memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs(1). These same factors, though, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency...

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Detalles Bibliográficos
Autores principales: Yurkovetskiy, Leonid, Guney, Mehmet Hakan, Kim, Kyusik, Goh, Shih Lin, McCauley, Sean, Dauphin, Ann, Diehl, William, Luban, Jeremy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258279/
https://www.ncbi.nlm.nih.gov/pubmed/30297740
http://dx.doi.org/10.1038/s41564-018-0256-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258279/
https://www.ncbi.nlm.nih.gov/pubmed/30297740
http://dx.doi.org/10.1038/s41564-018-0256-x

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