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Primate immunodeficiency virus Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex

Host factors that silence provirus transcription in CD4(+) memory T cells help HIV-1 escape eradication by the host immune system and by antiviral drugs(1). These same factors, though, must be overcome for HIV-1 to propagate. Here we show that Vpx and Vpr encoded by diverse primate immunodeficiency...

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Detalles Bibliográficos
Autores principales:	Yurkovetskiy, Leonid, Guney, Mehmet Hakan, Kim, Kyusik, Goh, Shih Lin, McCauley, Sean, Dauphin, Ann, Diehl, William, Luban, Jeremy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258279/ https://www.ncbi.nlm.nih.gov/pubmed/30297740 http://dx.doi.org/10.1038/s41564-018-0256-x

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