A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers

BACKGROUND: Mutations in KRAS are frequent in human cancer, yet effective targeted therapeutics for these cancers are still lacking. Attempts to drug the MEK kinases downstream of KRAS have had limited success in clinical trials. Understanding the specific genomic vulnerabilities of KRAS-driven canc...

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Detalles Bibliográficos
Autores principales: Šuštić, Tonći, van Wageningen, Sake, Bosdriesz, Evert, Reid, Robert J. D., Dittmar, John, Lieftink, Cor, Beijersbergen, Roderick L., Wessels, Lodewyk F. A., Rothstein, Rodney, Bernards, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258447/
https://www.ncbi.nlm.nih.gov/pubmed/30482246
http://dx.doi.org/10.1186/s13073-018-0600-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258447/
https://www.ncbi.nlm.nih.gov/pubmed/30482246
http://dx.doi.org/10.1186/s13073-018-0600-z

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