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Pooled extracellular receptor-ligand interaction screening using CRISPR activation
Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-af...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258485/ https://www.ncbi.nlm.nih.gov/pubmed/30477585 http://dx.doi.org/10.1186/s13059-018-1581-3 |