Multiple configurations of EGFR exon 20 resistance mutations after first- and third-generation EGFR TKI treatment affect treatment options in NSCLC

After sequential treatment with first- and third-generation EGFR tyrosine kinase inhibitors (TKIs), EGFR-mutant non-small cell lung cancers frequently harbor multiple resistance mutations in exon 20 of EGFR including T790M, mediating resistance to first-generation TKIs, and at codons 792, 796, or 79...

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Detalles Bibliográficos
Autores principales: Goldberg, Michael E., Montesion, Meagan, Young, Lauren, Suh, James, Greenbowe, Joel, Kennedy, Mark, Giaccone, Giuseppe, Akerley, Wallace L., Dowlati, Afshin, Creelan, Benjamin C., Hicks, James K., Hesketh, Paul J., Kelly, Karen L., Riess, Jonathan W., Miller, Vincent A., Stephens, Philip J., Frampton, Garrett M., Ali, Siraj, Gregg, Jeffrey P., Albacker, Lee A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258560/
https://www.ncbi.nlm.nih.gov/pubmed/30481207
http://dx.doi.org/10.1371/journal.pone.0208097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258560/
https://www.ncbi.nlm.nih.gov/pubmed/30481207
http://dx.doi.org/10.1371/journal.pone.0208097

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