Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration

Severe influenza A virus infection causes high mortality and morbidity worldwide due to delayed antiviral treatment and inducing overwhelming immune responses, which contribute to immunopathological lung injury. Sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), was effective in improv...

Descripción completa

Detalles Bibliográficos
Autores principales: Jia, Xuehong, Liu, Bo, Bao, Linlin, Lv, Qi, Li, Fengdi, Li, Hui, An, Yunqing, Zhang, Xulong, Cao, Bin, Wang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258564/
https://www.ncbi.nlm.nih.gov/pubmed/30422993
http://dx.doi.org/10.1371/journal.ppat.1007428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258564/
https://www.ncbi.nlm.nih.gov/pubmed/30422993
http://dx.doi.org/10.1371/journal.ppat.1007428

Ejemplares similares