Cargando…
Delayed oseltamivir plus sirolimus treatment attenuates H1N1 virus-induced severe lung injury correlated with repressed NLRP3 inflammasome activation and inflammatory cell infiltration
Severe influenza A virus infection causes high mortality and morbidity worldwide due to delayed antiviral treatment and inducing overwhelming immune responses, which contribute to immunopathological lung injury. Sirolimus, an inhibitor of mammalian target of rapamycin (mTOR), was effective in improv...
Autores principales: | Jia, Xuehong, Liu, Bo, Bao, Linlin, Lv, Qi, Li, Fengdi, Li, Hui, An, Yunqing, Zhang, Xulong, Cao, Bin, Wang, Chen |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258564/ https://www.ncbi.nlm.nih.gov/pubmed/30422993 http://dx.doi.org/10.1371/journal.ppat.1007428 |
Ejemplares similares
-
Vγ4(+)γδT Cells Aggravate Severe H1N1 Influenza Virus Infection-Induced Acute Pulmonary Immunopathological Injury via Secreting Interleukin-17A
por: Xue, Chunxue, et al.
Publicado: (2017) -
Ficolin A exacerbates severe H1N1 influenza virus infection-induced acute lung immunopathological injury via excessive complement activation
por: Wu, Xu, et al.
Publicado: (2021) -
Melatonin Alleviates Neonatal Necrotizing Enterocolitis by Repressing the Activation of the NLRP3 Inflammasome
por: Xiong, Xiaoyu, et al.
Publicado: (2022) -
The NLRP1 and CARD8 inflammasomes
por: Taabazuing, Cornelius Y., et al.
Publicado: (2020) -
The NLRP1 inflammasome in skin diseases
por: Burian, Marc, et al.
Publicado: (2023)