NF1 heterozygosity fosters de novo tumorigenesis but impairs malignant transformation

Neurofibromatosis type 1 (NF1) is an autosomal genetic disorder. Patients with NF1 are associated with mono-allelic loss of the tumor suppressor gene NF1 in their germline, which predisposes them to develop a wide array of benign lesions. Intriguingly, recent sequencing efforts revealed that the NF1...

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Detalles Bibliográficos
Autores principales: Brosseau, Jean-Philippe, Liao, Chung-Ping, Wang, Yong, Ramani, Vijay, Vandergriff, Travis, Lee, Michelle, Patel, Amisha, Ariizumi, Kiyoshi, Le, Lu Q.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258697/
https://www.ncbi.nlm.nih.gov/pubmed/30479396
http://dx.doi.org/10.1038/s41467-018-07452-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258697/
https://www.ncbi.nlm.nih.gov/pubmed/30479396
http://dx.doi.org/10.1038/s41467-018-07452-y

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