Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape

The mammalian inactive X-chromosome (Xi) is structurally distinct from all other chromosomes and serves as a model for how the 3D genome is organized. The Xi shows weakened topologically associated domains and is instead organized into megadomains and superloops directed by the noncoding loci, Dxz4...

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Detalles Bibliográficos
Autores principales: Froberg, John E., Pinter, Stefan F., Kriz, Andrea J., Jégu, Teddy, Lee, Jeannie T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258728/
https://www.ncbi.nlm.nih.gov/pubmed/30479398
http://dx.doi.org/10.1038/s41467-018-07446-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258728/
https://www.ncbi.nlm.nih.gov/pubmed/30479398
http://dx.doi.org/10.1038/s41467-018-07446-w

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