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Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape
The mammalian inactive X-chromosome (Xi) is structurally distinct from all other chromosomes and serves as a model for how the 3D genome is organized. The Xi shows weakened topologically associated domains and is instead organized into megadomains and superloops directed by the noncoding loci, Dxz4...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258728/ https://www.ncbi.nlm.nih.gov/pubmed/30479398 http://dx.doi.org/10.1038/s41467-018-07446-w |