A Novel Sensitive Immunoassay Targeting the 5-Methylthio-d-Xylofuranose–Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis

The only currently commercialized point-of-care assay for tuberculosis (TB) that measures lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient sensitivity. We evaluated the potential of 100 novel monoclonal antibody pairs targeting a variety of LAM epitopes on a sensitive electrochemilum...

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Detalles Bibliográficos
Autores principales: Sigal, George B., Pinter, Abraham, Lowary, Todd L., Kawasaki, Masanori, Li, Andra, Mathew, Anu, Tsionsky, Michael, Zheng, Ruixiang Blake, Plisova, Tatiana, Shen, Ke, Katsuragi, Kiyonori, Choudhary, Alok, Honnen, William J., Nahid, Payam, Denkinger, Claudia M., Broger, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Immunoassays
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258851/
https://www.ncbi.nlm.nih.gov/pubmed/30257899
http://dx.doi.org/10.1128/JCM.01338-18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258851/
https://www.ncbi.nlm.nih.gov/pubmed/30257899
http://dx.doi.org/10.1128/JCM.01338-18

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