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A Novel Sensitive Immunoassay Targeting the 5-Methylthio-d-Xylofuranose–Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis
The only currently commercialized point-of-care assay for tuberculosis (TB) that measures lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient sensitivity. We evaluated the potential of 100 novel monoclonal antibody pairs targeting a variety of LAM epitopes on a sensitive electrochemilum...
Autores principales: | Sigal, George B., Pinter, Abraham, Lowary, Todd L., Kawasaki, Masanori, Li, Andra, Mathew, Anu, Tsionsky, Michael, Zheng, Ruixiang Blake, Plisova, Tatiana, Shen, Ke, Katsuragi, Kiyonori, Choudhary, Alok, Honnen, William J., Nahid, Payam, Denkinger, Claudia M., Broger, Tobias |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258851/ https://www.ncbi.nlm.nih.gov/pubmed/30257899 http://dx.doi.org/10.1128/JCM.01338-18 |
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