Barcoding of Macaque Hematopoietic Stem and Progenitor Cells: A Robust Platform to Assess Vector Genotoxicity

Gene therapies using integrating retrovirus vectors to modify hematopoietic stem and progenitor cells have shown great promise for the treatment of immune system and hematologic diseases. However, activation of proto-oncogenes via insertional mutagenesis has resulted in the development of leukemia....

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Detalles Bibliográficos
Autores principales: Yabe, Idalia M., Truitt, Lauren L., Espinoza, Diego A., Wu, Chuanfeng, Koelle, Samson, Panch, Sandhya, Corat, Marcus A.F., Winkler, Thomas, Yu, Kyung-Rok, Hong, So Gun, Bonifacino, Aylin, Krouse, Allen, Metzger, Mark, Donahue, Robert E., Dunbar, Cynthia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258888/
https://www.ncbi.nlm.nih.gov/pubmed/30547048
http://dx.doi.org/10.1016/j.omtm.2018.10.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6258888/
https://www.ncbi.nlm.nih.gov/pubmed/30547048
http://dx.doi.org/10.1016/j.omtm.2018.10.009

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