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Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction

A Lewis acid-mediated three-component coupling reaction was successfully applied for the synthesis of lasofoxifene (1), nafoxidine (2), and their positional isomers, inv-lasofoxifene (3) and inv-nafoxidine (4). In the presence of HfCl(4), the desired one-pot coupling reaction among 4-pivaloyloxybenz...

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Detalles Bibliográficos
Autores principales: Nakata, Kenya, Sano, Yoshiyuki, Shiina, Isamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259163/
http://dx.doi.org/10.3390/molecules15106773