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Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)

Three antimicrobial sphingolipids were separated by bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems and identified as (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-gluco...

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Autores principales: Tang, Jing, Meng, Xiangjie, Liu, Hao, Zhao, Jianglin, Zhou, Ligang, Qiu, Minghua, Zhang, Xianming, Yu, Zhu, Yang, Fuyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259170/
https://www.ncbi.nlm.nih.gov/pubmed/21160453
http://dx.doi.org/10.3390/molecules15129288
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author Tang, Jing
Meng, Xiangjie
Liu, Hao
Zhao, Jianglin
Zhou, Ligang
Qiu, Minghua
Zhang, Xianming
Yu, Zhu
Yang, Fuyu
author_facet Tang, Jing
Meng, Xiangjie
Liu, Hao
Zhao, Jianglin
Zhou, Ligang
Qiu, Minghua
Zhang, Xianming
Yu, Zhu
Yang, Fuyu
author_sort Tang, Jing
collection PubMed
description Three antimicrobial sphingolipids were separated by bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems and identified as (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-glucopyranosyl(2S,3S,4R,10E)-2-[(2'R)-2-hydroxy-tetracosanoylamino]-1,3,4-octadecanetriol-10-ene (2) and soya-cerebroside I (3) by their physicochemical properties and spectroscopic analysis. They were evaluated to show antifungal and antibacterial activity on test microorganisms including four fungal and three bacterial species. Among them, compound 1, a relatively low polarity aglycone, exhibited stronger antimicrobial activity than its corresponding glycoside 2. The results indicated that sphingolipids could be the main antimicrobial compounds in the crude methanol extract of cucumber stems.
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spelling pubmed-62591702018-12-06 Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) Tang, Jing Meng, Xiangjie Liu, Hao Zhao, Jianglin Zhou, Ligang Qiu, Minghua Zhang, Xianming Yu, Zhu Yang, Fuyu Molecules Article Three antimicrobial sphingolipids were separated by bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems and identified as (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-glucopyranosyl(2S,3S,4R,10E)-2-[(2'R)-2-hydroxy-tetracosanoylamino]-1,3,4-octadecanetriol-10-ene (2) and soya-cerebroside I (3) by their physicochemical properties and spectroscopic analysis. They were evaluated to show antifungal and antibacterial activity on test microorganisms including four fungal and three bacterial species. Among them, compound 1, a relatively low polarity aglycone, exhibited stronger antimicrobial activity than its corresponding glycoside 2. The results indicated that sphingolipids could be the main antimicrobial compounds in the crude methanol extract of cucumber stems. MDPI 2010-12-15 /pmc/articles/PMC6259170/ /pubmed/21160453 http://dx.doi.org/10.3390/molecules15129288 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Tang, Jing
Meng, Xiangjie
Liu, Hao
Zhao, Jianglin
Zhou, Ligang
Qiu, Minghua
Zhang, Xianming
Yu, Zhu
Yang, Fuyu
Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)
title Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)
title_full Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)
title_fullStr Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)
title_full_unstemmed Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)
title_short Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)
title_sort antimicrobial activity of sphingolipids isolated from the stems of cucumber (cucumis sativus l.)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259170/
https://www.ncbi.nlm.nih.gov/pubmed/21160453
http://dx.doi.org/10.3390/molecules15129288
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