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Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.)
Three antimicrobial sphingolipids were separated by bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems and identified as (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-gluco...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259170/ https://www.ncbi.nlm.nih.gov/pubmed/21160453 http://dx.doi.org/10.3390/molecules15129288 |
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author | Tang, Jing Meng, Xiangjie Liu, Hao Zhao, Jianglin Zhou, Ligang Qiu, Minghua Zhang, Xianming Yu, Zhu Yang, Fuyu |
author_facet | Tang, Jing Meng, Xiangjie Liu, Hao Zhao, Jianglin Zhou, Ligang Qiu, Minghua Zhang, Xianming Yu, Zhu Yang, Fuyu |
author_sort | Tang, Jing |
collection | PubMed |
description | Three antimicrobial sphingolipids were separated by bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems and identified as (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-glucopyranosyl(2S,3S,4R,10E)-2-[(2'R)-2-hydroxy-tetracosanoylamino]-1,3,4-octadecanetriol-10-ene (2) and soya-cerebroside I (3) by their physicochemical properties and spectroscopic analysis. They were evaluated to show antifungal and antibacterial activity on test microorganisms including four fungal and three bacterial species. Among them, compound 1, a relatively low polarity aglycone, exhibited stronger antimicrobial activity than its corresponding glycoside 2. The results indicated that sphingolipids could be the main antimicrobial compounds in the crude methanol extract of cucumber stems. |
format | Online Article Text |
id | pubmed-6259170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62591702018-12-06 Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) Tang, Jing Meng, Xiangjie Liu, Hao Zhao, Jianglin Zhou, Ligang Qiu, Minghua Zhang, Xianming Yu, Zhu Yang, Fuyu Molecules Article Three antimicrobial sphingolipids were separated by bioassay-guided isolation from the chloroform fraction of the crude methanol extract of cucumber (Cucumis sativus L.) stems and identified as (2S,3S,4R,10E)-2-[(2'R)-2-hydroxytetra-cosanoylamino]-1,3,4-octadecanetriol-10-ene (1), 1-O-β-D-glucopyranosyl(2S,3S,4R,10E)-2-[(2'R)-2-hydroxy-tetracosanoylamino]-1,3,4-octadecanetriol-10-ene (2) and soya-cerebroside I (3) by their physicochemical properties and spectroscopic analysis. They were evaluated to show antifungal and antibacterial activity on test microorganisms including four fungal and three bacterial species. Among them, compound 1, a relatively low polarity aglycone, exhibited stronger antimicrobial activity than its corresponding glycoside 2. The results indicated that sphingolipids could be the main antimicrobial compounds in the crude methanol extract of cucumber stems. MDPI 2010-12-15 /pmc/articles/PMC6259170/ /pubmed/21160453 http://dx.doi.org/10.3390/molecules15129288 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Tang, Jing Meng, Xiangjie Liu, Hao Zhao, Jianglin Zhou, Ligang Qiu, Minghua Zhang, Xianming Yu, Zhu Yang, Fuyu Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) |
title | Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) |
title_full | Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) |
title_fullStr | Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) |
title_full_unstemmed | Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) |
title_short | Antimicrobial Activity of Sphingolipids Isolated from the Stems of Cucumber (Cucumis sativus L.) |
title_sort | antimicrobial activity of sphingolipids isolated from the stems of cucumber (cucumis sativus l.) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259170/ https://www.ncbi.nlm.nih.gov/pubmed/21160453 http://dx.doi.org/10.3390/molecules15129288 |
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